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. 2019 Jul 19;14(4):441–451. doi: 10.1007/s11523-019-00656-2
This is the first study to prospectively investigate drug-induced interstitial lung disease and the value of diverse diagnostic biomarkers to discriminate ILD from alternate diagnoses.
Diffusion capacity and the plasma biomarkers YKL-40 and SP-D can differentiate everolimus-induced ILD from alternate causes.
A rapid decrease in diffusion capacity could be an indication of severe ILD needing treatment discontinuation.