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. 2019 Aug 6;9:11410. doi: 10.1038/s41598-019-47928-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LocusZoom plot (top) and forest plot (bottom) of the SYBU locus, detected as associated with the ankle brachial index (ABI) in the Caribbean group. In the locusZoom plots, each point represents a variant, with location marked on the x-axis, and p-values marked as the location on the y-axis. The lead SNP is represented by the triangle, indicating that it is imputed. The colors of the variants correspond to the strength of their LD (r²) with the lead SNP, with LD estimated using the combined population of the HCHS/SOL Caribbean group. Circles correspond to genotyped variants, x symbols to imputed variants. The p-value of heterogeneity (across all HCHS/SOL genetic analysis groups) was 9.3 × 10⁻⁴. The bottom of the forest plot provides results from MESA replication groups.