Table 1.
Cardiorespiratory Measurements during Awake and Sleep States
RMSSD square root of the mean of the sum of squares of the RR-interval differences, QTcB refers to corrected QT-interval using the Bazett formula (milliseconds) as well as mean QT in parentheses, CB control baboon, EB1&2 epileptic baboons, Tx (VNS therapy), GTCS generalized tonic-clonic seizures, wk week, NA not applicable, statistically significant (two-tailed T-Test, p < 0.05) differences between * CB and EB1 baseline, ‡ CB - EB2 and EB2 baseline (except for QTcB), ∫ pre- and post-treatment in either EB1 or EB2, and # EB1 or EB2 both pre- and post-treatment.
| Baboon | Epochs | Heart Rate | RR-intervals | RMSSD | QTcB | |
|---|---|---|---|---|---|---|
| CB | Overall Awake Sleep |
113 +/− 23‡ 136 +/− 17‡ 98 +/− 13‡ |
551 +/− 109*‡ 449 +/− 54*‡ 620 +/− 78*‡ |
32 +/− 30*‡ 12 +/− 8* 46 +/− 31*‡ |
352 +/− 6*‡ (QT 258) |
|
| EB1 | Pre-Tx (1 GTCS/wk)13 |
Overall Awake Sleep |
114 +/− 12∫# 124 +/− 9∫# 106 +/− 7∫# |
530 +/− 54*∫# 486 +/− 37*∫# 566 +/− 38*∫# |
11 +/− 7*∫# 6+/−5*∫# 14 +/− 7*∫# |
380 +/− 7* (QT 281) |
| Post-Tx (no GTCS)13 |
Overall Awake Sleep |
111 +/− 12∫# 118 +/− 11∫# 105 +/− 10∫# |
549 +/− 59∫# 511 +/− 48∫# 578 +/− 49∫# |
19 +/− 17∫# 11 +/− 7∫ 25 +/− 11∫# |
382 +/− 16# (QT 277) |
|
| EB2 | Pre-Tx (3 GTCS/wk)13 |
Overall Awake Sleep |
132 +/− 22‡∫# 150 +/− 16‡∫# 114 +/− 9‡∫# |
468 +/− 78‡∫# 405 +/− 51‡∫# 532 +/− 40‡∫# |
29 +/− 29∫# 12 +/− 12# 46 +/− 31∫# |
NA |
| Post-Tx (2 GTCS/wk)13 |
Overall Awake Sleep |
128 +/− 16∫# 138 +/− 14∫# 119 +/− 11∫# |
475 +/− 57∫# 437 +/− 48∫# 507 +/− 44∫# |
20 +/− 14∫# 12 +/− 9 27 +/− 14∫# |
370 +/− 4‡# (QT 250) |
|