Sexual behavior in WT (n=9), MC4RKO (n=9), and tbMC4Roxt (n=6) mice. WT and MC4RKO data repeated for clarity. (A) tbMC4Roxt mice had a similar weight to MC4RKO mice and both groups weighed significantly more than WT controls. (B) Mounting attempts between MC4RKO and all other groups was significantly different by one-way ANOVA, with Bonferroni’s post-tests. (C) Intromission number was not significantly different between MC4RKO and all other littermates. (D) The ratio of successful intromission to mounting attempts, an indicator of intromission efficiency, was not significant across groups. (E) Latency to Ejaculation was significantly increased in MC4RKO mice compared to all other groups. *=compared to WT, ^=compared to MC4RKO