Table 2.
Certain defensin subfamily members that are cationic and cysteine-rich antimicrobial peptides
| Defensins | Sequence | Cys Residues | Secondary Structure | Length (Amino acids) | Organism | PDB ID |
|---|---|---|---|---|---|---|
| α-defensin 1 | ACYCRIPACI AGERRYGTCI YQGRLWAFCC | 6 | 53% beta sheet (3 strands; 16 residues) | 30 | Homo sapiens | 3GNY |
| α-defensin 4 | VCSCRLVFCR RTELRVGNCL IGGVSFTYCC TRV | 6 | 57% beta sheet (3 strands; 19 residues) | 33 | Homo sapiens | 1ZMM |
| α-defensin 5 | ATCYCRTGRC ATRESLSGVC EISGRLYRLC CR | 6 | 59% beta sheet (3 strands; 19 residues) | 32 | Homo sapiens | 1ZMP |
| α-defensin 6 | AFTCHCRRSC YSTEYSYGTC TVMGINHRFC CL | 6 | 65% beta sheet (3 strands; 21 residues) | 32 | Homo sapiens | 1ZMQ |
| β-defensin 1 | DHYNCVSSGG QCLYSACPIF TKIQGTCYRG KAKCCK | 6 | 16% helical (1 helices; 6 residues) | 36 | Homo sapiens | 1IJU |
| 33% beta sheet (3 strands; 12 residues) | ||||||
| β-defensin 2 | GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P | 6 | 14% helical (1 helices; 6 residues) | 41 | Homo sapiens | 1FD3 |
| 31% beta sheet (5 strands; 13 residues) | ||||||
| β-defensin 3 | GIINTLQKYY CRVRGGRCAV LSCLPKEEQI GKCSTRGRKC CRRKK | 6 | 11% helical (1 helices; 5 residues) | 45 | Homo sapiens | 1KJ6 |
| 28% beta sheet (3 strands; 13 residues) | ||||||
| β-defensin 4 | EFELDRICGY GTARCRKKCR SQEYRIGRCP NTYACCLRKW DES | 6 | 6% helical (1 helices; 3 residues) | 43 | Homo sapiens | 5KI9 |
| 39% beta sheet (4 strands; 17 residues) | ||||||
| Antifungal heliomicin | DKLIGSCVWG AVNYTSDCNG ECKRRGYKGG HCGSFANVNC WCET | 6 | 15% helical (1 helices; 7 residues) | 44 | Heliothis virescens | 1I2U |
| 29% beta sheet (4 strands; 13 residues) | ||||||
| Defensin-like peptide-2 | IMFFEMQACW SHSGVCRDKS ERNCKPMAWT YCENRNQKCC EY | 6 | 9% helical (1 helices; 4 residues) | 42 | Ornithorhynchus anatinus | 1D6B |
| 21% beta sheet (3 strands; 9 residues) | ||||||
| Sugarcane defensin 5 | HTPTPTPICK SRSHEYKGRC IQDMDCNAAC VKESESYTGG FCNGRPPFKQ CFCTKPCKRE RAAATLRWPG L | 8 | 15% helical (1 helices; 11 residues) | 71 | Saccarum officinarum | 2KSK |
| 21% beta sheet (3 strands; 15 residues) |
Date were collected and referred from RCSB PDB (Research Collaborative for Structural Bioinformatics Protein Data Bank) (Website: https://www.rcsb.org).