Table 1.
Cardiac function determined by echocardiography at baseline and endpoint
| LVEF (%) | LVFS (%) | LVEDd (mm) | LVESd (mm) | ||
|---|---|---|---|---|---|
| Sham | Baseline | 82.53±3.82 | 44.55±4.20 | 6.61±0.30 | 3.66±0.2 |
| Endpoint | 82.56±1.74 | 44.41±1.91 | 6.40±0.36 | 3.56±0.15 | |
| Changes | 0.03±3.08 | -0.14±3.28 | -0.21±0.25 | -0.10±0.24 | |
| AMI | Baseline | 51.25±3.09 | 21.46±1.69 | 6.72±0.38 | 5.27±0.23 |
| Endpoint | 45.70±3.18 | 19.29±1.70 | 8.51±0.45 | 6.86±0.35 | |
| Changes | -5.55±2.52 | -2.17±1.56 | 1.79±0.54 | 1.59±0.46 | |
| MSCs | Baseline | 50.88±1.56 | 21.24±1.15 | 6.43±0.36 | 5.07±0.32 |
| Endpoint | 56.45±2.12 | 24.73±1.63 | 8.34±0.31 | 6.28±0.33 | |
| Changes | 5.58±3.13* | 3.49±2.14* | 1.91±0.63$ | 1.21±0.61$ | |
| ATV | Baseline | 50.60±3.41 | 21.13±2.16 | 6.94±0.40 | 5.47±0.33 |
| Endpoint | 56.59±1.83 | 24.98±1.46 | 8.17±0.32 | 6.13±0.31 | |
| Changes | 5.99±3.98* | 3.85±2.11* | 1.23±0.59# | 0.66±0.51*,# | |
| ATV+MSCs | Baseline | 51.71±2.53 | 21.57±1.39 | 6.87±0.23 | 5.39±0.25 |
| Endpoint | 64.5±1.90 | 29.77±1.81 | 7.85±0.22 | 5.51±0.16 | |
| Changes | 12.79±2.11*,#,$ | 8.20±1.76*,#,$ | 0.98±0.30*,#,$ | 0.12±0.22*,# | |
| ATV-MSCs | Baseline | 52.24±1.23 | 21.84±0.67 | 6.82±0.22 | 5.33±0.19 |
| Endpoint | 63.13±1.29 | 28.67±1.40 | 7.60±0.35 | 5.42±0.24 | |
| Changes | 10.89±1.66*,#,$ | 6.84±1.54*,#,$ | 0.77±0.38*,#,$ | 0.08±0.30*,#,$ | |
| ATV+ATV-MSCs | Baseline | 51.17±2.58 | 21.41±1.43 | 6.78±0.21 | 5.33±0.21 |
| Endpoint | 67.01±1.38 | 31.27±1.21 | 7.48±0.19 | 5.14±0.13 | |
| Changes | 15.84±2.85*,#,$,& | 9.86±1.54*,#,$,& | 0.70±0.29*,#,$ | -0.19±0.24*,#,$ | |
| ATV+ATV-MSCs+AMD3100 | Baseline | 52.51±2.13 | 22.13±1.31 | 6.65±0.27 | 5.18±0.22 |
| Endpoint | 54.22±1.67 | 23.29±0.88 | 8.65±0.28 | 6.63±0.23 | |
| Changes | 1.71±2.47*,$,&,£ | 1.15±1.57*,&,£ | 2.00±0.45$,&,£ | 1.46±0.38$,&,£ |
ATV: atorvastatin; MSCs: mesenchymal stem cells; ATV-MSCs: atorvastatin pretreated mesenchymal stem cells; AMI: acute myocardial infarction; LVEF: left ventricular ejection fraction; LVFS: left ventricular fractional shortening; LVEDd: left ventricular end-diastolic dimension; LVESd: left ventricular end-systolic dimension. n = 10 for each group.
*
P<0.05 compared with AMI group;
#
P<0.05 compared with MSCs group;
$
P<0.05 compared with ATV group;
&
P<0.05 compared with ATV-MSCs group;
£
P<0.05 compared with ATV+ATV-MSCs group.