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. 2019 Jul 15;11(7):4508–4515.

Figure 2.

Figure 2

Anti-tumor effect of PRO-007 in the FGFR2-amplified GC cell line. A. Pro-007 suppressed proliferation in FGFR2-amplified KATOIII cells. Cell proliferation was measured by the CTG assay after treatment with PRO-007 at 10 μg/ml for 72 h. Cell viability (%) represents the percentage of growth compared to that of the control (no treatment). B. Pro-007 suppressed KATOIII cell invasion. Cells that invaded the membrane were stained with crystal violet and counted directly under a microscope. Data are presented as mean values ± SD of three independent experiments. C. Pro-007 decreased FGFR phosphorylation and targeted downstream pathways. D. Pro-007 (1 μg/ml) enhances the efficacy of ramucirumab (1 μM) in FGFR2-amplified KATOIII cells.