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. 2019 Jul 15;11(7):4277–4289.

Figure 4.

Figure 4

STAT3 mediates the Snail expression in TMZ resistant GBM cells. (A) The relative Snail mRNA expression level in 16 pairs of primary and recurrent GBM tumors. (B) The relative Snail mRNA expression level in A172P, A172R, U87P and U87R cells. (C) The expression of indicated proteins in GBM1, GBM2, A172P, A172R, U87P and U87R cells. (D) The binding of STAT3 or p65 with Snail promoter was detected by CHIP assay. (E) A172R cells were transfected with control or STAT3 siRNA, and treated with 10 µM TMZ for 24 h. The expression of indicated proteins was detected by western blot. (F) The mRNA level of Snail in A172R cells transfected with control or STAT3 siRNA. (G) The apoptosis of A172R cells treated as in (E). (H) The cell migration and invasion of A172R cells transfected with control or Snail siRNA. **, P<0.01.