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. 2019 Jul 15;11(7):4326–4336.

Figure 5.

Figure 5

Atg7 siRNA increased VSMCs foam cell formation by inhibition of miR-223-induced autophagy. A and B. The protein expression level of Atg7 was significantly decreased by Atg7 siRNA, as detected by western blot analysis (n = 5). C-E. LC3II/LC3I ratio and beclin-1 level were decreased whereas the expression of p62 was minimally increased by Atg7 siRNA, as determined by western blot analysis (n = 5). F and G. Lipid droplet accumulation and intracellular cholesterol contents measurement (n = 4 for both) in ox-LDL-treated VSMCs transfected with negative control (50 nmol/L), miR-223 mimic (50 nmol/L) or Atg7 siRNA (50 nmol/L). *P < 0.05, **P < 0.01, ***P < 0.001.