Table 2. Association between analyzed SLC5A2 single nucleotide polymorphisms and traits of glucose hemostasis in the total study cohort.
| n | HbA1c (%) | Fasting glucose (mmol/l) | 120 min glucose (mmol/l) | Fasting insulin (µU/ml) | HOMA IR | HOMA BCF | |
|---|---|---|---|---|---|---|---|
| rs9934336 | |||||||
| GG | 939 (55.8%) | 6.13 ± 1.05 | 6.3 ± 2.06 | 8.04 ± 4.37 | 13.14 ± 30.92 | 4.13 ± 14.77 | 104.42 ± 117.4 |
| GA | 638 (37.9%) | 6.06 ± 0.96 | 6.16 ± 1.88 | 7.7 ± 4.11 | 11.47 ± 10.61 | 3.44 ± 4.91 | 98.98 ± 71.26 |
| AA | 107 (6.4%) | 5.94 ± 0.78 | 5.93 ± 1.29 | 7.11 ± 3.19 | 10.98 ± 8.13 | 3.12 ± 3.11 | 96.49 ± 52.93 |
| P-value | 0.023 | 0.044 | 0.049 | 0.235 | 0.075 | 0.584 | |
| rs3813008 | |||||||
| GG | 1267 (75.2%) | 6.09 ± 1.01 | 6.2 ± 1.9 | 7.66 ± 4.03 | 12.56 ± 26.91 | 3.92 ± 12.94 | 102.73 ± 103.75 |
| GA | 395 (23.5%) | 6.09 ± 0.95 | 6.28 ± 2.07 | 8.35 ± 4.62 | 11.64 ± 10.03 | 3.36 ± 3.18 | 99.42 ± 81.47 |
| AA | 22 (1.3%) | 6.36 ± 1.46 | 6.71 ± 2.91 | 9.47 ± 5.89 | 12.59 ± 9.76 | 4.62 ± 6.28 | 90.42 ± 54.84 |
| P-value | 0.355 | 0.221 | 0.019 | 0.626 | 0.880 | 0.329 | |
| rs3116150 | |||||||
| GG | 940 (55.8%) | 6.06 ± 0.99 | 6.18 ± 1.96 | 7.92 ± 4.23 | 11.51 ± 9.68 | 3.41 ± 4.15 | 99.81 ± 80.95 |
| GA | 634 (37.6%) | 6.12 ± 1.01 | 6.27 ± 1.96 | 7.69 ± 4.17 | 13.76 ± 37.3 | 4.44 ± 17.94 | 105.56 ± 124.23 |
| AA | 110 (6.5%) | 6.18 ± 1.05 | 6.28 ± 1.84 | 8.05 ± 4.25 | 11.66 ± 8.12 | 3.51 ± 3.42 | 97.82 ± 68.3 |
| P-value | 0.147 | 0.239 | 0.513 | 0.377 | 0.255 | 0.898 | |
Analyses were performed by multiple linear regression analysis using sex, age, and body mass index as covariates under an additive model of inheritance. All variables were log-transformed prior to statistical analysis. Data are presented as mean ± SD of non-log-transformed values.
Abbreviations: HbA1c, hemoglobin A1c; HOMA BCF, homeostasis model of assessment beta-cell function; HOMA IR, homeostasis model assessment of insulin resistance; SD, standard deviation.