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. 2019 Jul 31;16(156):20190230. doi: 10.1098/rsif.2019.0230

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© 2019 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 2. — First incomplete moments of 2D simulations. (a–c) First incomplete moments of 2D simulations (Methods). The average of 1000 simulations is shown in black, a selection of 20 individual simulations is shown in blue. (a) Neutral simulations. (b) Simulations where 1% of mutations are non-neutral. A deviation from the straight line is seen at clone sizes of approximately 100 cells. (c) Simulations where 25% of mutations are non-neutral. (d) Proportion of cells at the end of the simulations with a fitness altered by non-neutral mutations. In the 25% non-neutral simulations, by the end of the simulation, almost the entirety of the tissue has been colonized by non-neutral mutant clones. (e) dN/dS values from the simulations shown in (a–c). To enable this calculation for the neutral simulations, a proportion of neutral mutations were labelled as non-neutral but did not affect cell fitness. (Online version in colour.)