Figure 1.

Regulation of reaction fluxes via changes in the intracellular localization of enzymes. At a branch point in a reaction network, the sequestration of one downstream enzyme (here called E_P) into clusters can direct the reaction flux away from the reaction catalysed by the sequestered enzyme. By contrast, co-clustering of the upstream enzyme E_I with the downstream enzyme E_P can bias the flux towards the product P. We analyse the effectiveness of these spatial regulation strategies within a reaction–diffusion model. Geometrical parameters of this model are illustrated on the right-hand side. (Online version in colour.)