ATM |
Mice (XlfΔ/ΔAtm−/−) |
V(D)J recombination, B- and T-cell development, C-NHEJ-mediated CSR |
[67] |
H2AX |
Mice (XlfΔ/ΔH2ax−/−, XlfΔ/ΔH2axF/F) |
V(D)J recombination, End-protection |
[67] |
PAXX |
G1 phase enriched murine v-Abl cells |
Sensitivity to ionizing radiation-induced DSBs |
[75–78] |
PAXX |
Mice |
Viability |
[76] |
53BP1 |
v-Abl transformed pro-B murine cell lines generated from WT, XlfΔ/Δ, 53bp1−/−, and XlfΔ/Δ53pb1−/− mice |
Lymphocyte development, V(D)J recombination |
[70,71] |
DNA-PKcs |
Mice (XlfΔ/ΔDna-PKcs−/−) |
Growth/viability; V(D)J recombination (signal joints) and NHEJ; CSR |
[72] |
RAG |
Mice (Rag2c/cXlf−/−p53−/−) |
Lymphocyte development at the progenitor stage |
[69] |