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. Author manuscript; available in PMC: 2019 Aug 7.
Published in final edited form as: DNA Repair (Amst). 2017 Aug 18;58:29–37. doi: 10.1016/j.dnarep.2017.08.003

Table I.

XLF Redundancies

Protein System Function References
ATM Mice (XlfΔ/ΔAtm−/−) V(D)J recombination, B- and T-cell development, C-NHEJ-mediated CSR [67]
H2AX Mice (XlfΔ/ΔH2ax−/−, XlfΔ/ΔH2axF/F) V(D)J recombination, End-protection [67]
PAXX G1 phase enriched murine v-Abl cells Sensitivity to ionizing radiation-induced DSBs [75–78]
PAXX Mice Viability [76]
53BP1 v-Abl transformed pro-B murine cell lines generated from WT, XlfΔ/Δ, 53bp1−/−, and XlfΔ/Δ53pb1−/− mice Lymphocyte development, V(D)J recombination [70,71]
DNA-PKcs Mice (XlfΔ/ΔDna-PKcs−/−) Growth/viability; V(D)J recombination (signal joints) and NHEJ; CSR [72]
RAG Mice (Rag2c/cXlf−/−p53−/−) Lymphocyte development at the progenitor stage [69]