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. 2018 Dec 4;3(45):12824–12829. doi: 10.1002/slct.201803375

Figure 4.

Figure 4

Evaluation of modified oligonucleotide 4 b as an inhibitor of SNM1A. a) Representative digestion of oligonucleotide 5 a by SNM1A (25 fmol, 2.5 nM) in the presence of 3.3 equivalents of oligonucleotide 4 b or 6 b (2.7 pmol, 264 nM) relative to 5 a (0.8 pmol, 80 nM) after 10 min with 5 min preincubation. b) Quantification of digestion of oligonucleotide 5 a by SNM1A (25 fmol, 2.5 nM) in the presence of 3.3 equivalents of oligonucleotide 4 b or 6 b (2.6 pmol, 264 nM) relative to 5 a (0.8 pmol, 80 nM) after 10 min with 5 min preincubation. Values represent the mean ±SD carried out for n=9 independent experiments performed in triplicate. nt=nucleotides.