FIGURE 4.

Allele variants of tpr genes found among examined clinical samples. To overcome the paralogous character of tpr genes, these loci were PCR amplified using primers with unique binding sites upstream and downstream the genes. The details are given in the section “Materials and Methods”. The allele variants are presented as a different color code (see legend under the figure). The blank spaces (e.g., tprE in CW87 and CW82; tprJ in CW86) represent genome regions which were not amplifiable in the given samples. TprK variants are missing due to their hyper-variable sequences based on different subpopulations of the same strain. The tprC allelic variants are shown in Supplementary Figure S2.