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. 2019 Jul 31;13:746. doi: 10.3389/fnins.2019.00746

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Copyright © 2019 Lin, Liu, Huang, Su, Chen, Gao, Tian, Huang, Zhen, Han, Ye and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical scores before, during, and after treatment in patient 1 and patient 2. (A) The CRS-R, GCS, FOUR, and CNC scores in patient 1. Compared to baseline, the CRS-R and CNC scores improved considerably, and the effect lasted for up to 1 month. (B) The subscales of the CRS-R score in patient 1. The arousal and auditory functions were the first to show improvement during stimulation. Then, communication improved. Finally, visual function and motor function improved after stimulation treatment was completed. (C) The CRS-R, GCS, FOUR, and CNC scores in patient 2. Compared to baseline, the scores did not show much improvement after 2 weeks of treatment. CRS-R, Coma Recovery Scale-Revised; GCS, Glasgow Coma Scale; FOUR, Full Outline of UnResponsiveness; CNC, Coma/Near Coma Scale.