Table 1.
Effect of 2′-FL supplementation on the immunoglobulin levels in plasma.
| Day 8 | Day 16 | |||
|---|---|---|---|---|
| μg/mL | REF | 2′-FL | REF | 2′-FL |
| IgM | 5.65 ± 0.19 | 5.74 ± 0.31 | 19.49 ± 0.75 | 18.83 ± 1.15 |
| IgG | 2123.26 ± 78.15 | 2454.14 ± 76.43* | 3693.28 ± 180.15 | 5732.33 ± 284.11* |
| IgG1 | 112.53 ± 3.00 | 105.36 ± 7.14 | 273.60 ± 6.67 | 296.84 ± 33.20 |
| IgG2a | 476.66 ± 24.12 | 483.95 ± 12.71 | 722.84 ± 17.44 | 884.24 ± 25.87* |
| IgG2b | 558.21 ± 51.12 | 834.30 ± 37.10* | 1055.80 ± 26.15 | 2452.3 ± 166.19* |
| IgG2c | 975.86 ± 78.55 | 1030.52 ± 28.18 | 1641.03 ± 170.39 | 2098.97 ± 79.03* |
| Th1/Th2 | 2.65 ± 0.18 | 3.16 ± 0.05* | 2.71 ± 0.18 | 3.85 ± 0.17* |
| IgA | 38.88 ± 3.06 | 45.37 ± 1.88 | 63.32 ± 1.49 | 90.15 ± 3.37* |
Results are expressed as mean ± S.E.M. (n = 8/group).
*
p < 0.05 compared to REF (by Mann–Whitney U-test).
Th1/Th2 = (IgG2b+IgG2c)/(IgG1+IgG2a).
REF, Reference; 2′-FL, 2′-fucosyllactose.