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. 2019 Jul 31;10:1791. doi: 10.3389/fimmu.2019.01791

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Copyright © 2019 Mikkelsen, Harwood, Compte, Merino, Mølgaard, Lykkemark, Alvarez-Mendez, Blanco and Álvarez-Vallina.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic diagrams showing the genetic (left) and domain structure (right) of the bispecific 1D8^N/CCEA.1 trimerbody (A), and the monospecific 1D8^N18 (B) and CEA.1^N17 (C) trimerbodies. The variable regions (V_L-V_H) derived from 1D8 antibody are represented in red/orange, the anti-CEA V_HH CEA.1 in light green, the TIE^XVIII domains in light blue, and the linker regions in gray. All the trimerbodies contain a signal peptide from oncostatin M (white box), and a His6-myc tag (dark green box). Arrows indicate the direction of transcription.