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. 2019 Aug 7;7:128. doi: 10.1186/s40478-019-0775-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Regulation of ETS-factors by oncogenic BRAF signaling. a mRNA and (b) protein expression/phosphorylation levels of ETS1/GABPA upon 16 h at 1 μM (qRT-PCR) and 6 h at 1 μM (Western blot) dabrafenib treatment. Fold values are given as normalized expression to β-actin and subsequent calculation of the ratio phospho/total ETS1 and are normalized to the respective untreated controls. mRNA expression levels of (c) GABPA, (d) GABPB-1S, (e) GABPB-1 L, and (f) GABPB-2 are depicted for the indicated cell models upon dabrafenib treatment (1 μM, 16 h). *p < 0.05, **p < 0.01, ***p < 0.001 (unpaired students’ t-tests); All values are given as mean +/− SD; wt = wild-type, mut = mutated, dabra = dabrafenib