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. 2019 Aug 6;7:207. doi: 10.1186/s40425-019-0687-9

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — A working model of the action of MICA α3-specific antibody alone and of MICA immune complex. A working model is proposed to illustrate 1) shed MICA blocks NKG2D mediated cellular interactions with surface-bound MICA (left panel); and 2) MICA α3-specific antibody can form immune complexes with sMICA leading to NKG2D and Fc-dependent NK cell activation (left panel); 3) MICA α3-specific antibody induces ADCC-mediated tumor cell killing and augments NKG2D signaling by stabilizing tumor surface MICA (right panel)