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. Author manuscript; available in PMC: 2019 Aug 7.
Published in final edited form as: Antiviral Res. 2018 Apr 14;154:104–109. doi: 10.1016/j.antiviral.2018.04.012

Figure 3: Impact of NITD-008 on Dengue caused by DENV-4 strain TVP376 in AG129 mice.

Figure 3:

Survival curve (A) and viremia levels (B) in 6–8 week old AG129 mice inoculated with 7.0 log10 pfu DENV-4 TVP 376 and treated twice daily for 4 days with NITD-008 (20mg/kg in 0.1ml) or vehicle by oral gavage beginning immediately after virus inoculation. Animals were monitored for 4 weeks. Viremia measured in half of the animals from each group on day 2 p.i. and the remaining animals on day 3 p.i. and quantitated by RT-PCR. *p<0.05, and ***p<0.005 (Student’s t-test compared to vehicle controls).