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. 2019 Aug 6;19:202. doi: 10.1186/s12906-019-2620-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Study Design. Legend: This figure shows the formulation of the trial, including the randomization process, phase 1, washout, and phase 2 periods. Also, it shows the groups 1 and 2 as experimental group (EG) and control group (CG), respectively, and their cross-over during the follow up. In addition, four reference points for evaluations 1–4 are pointed out. Each evaluation was comprised by full assessment, including anamnesis, 24-h dietary recall, indirect calorimetry, dual-energy X-ray absorptiometry, blood collection, and biochemical analysis