Table 2.

Roles of non-coding RNAs in hemodynamics-modulated endothelial function and dysfunction

	Non-coding RNA	Classification	Direct target	Affected molecule	EC dysfunction/function	Ref
Pro-atherogenic OS	miR
	miR-126-5p↓	Antiproliferative miR	Dlk1↑		Proliferation	81
	miR-10a↓	Anti-inflamatory miR	GATA6↑	VCAM-1↑	Inflammation	60, 76
			TAK1, βTRC↑	NF-κB p65 ↑	Inflammation	74
				E-sel, VCAM-1, ↑	Inflammation	74
				IL-6, IL-8, MCP-1↑	Inflammation	74
	miR-92a↑	Inflammatory miR	KLF2↓	IL-6, MCP-1 ↑,TM↓	Inflammation	82
	miR-663↑	Inflammatory miR	?	KLF4↓	Inflammation	73
	miR-712↑	Inflammatory miR	↓TIMP	Souluble TNF-α↑	Inflammation	75
	miR-21↑	Inflammatory miR	↓PPARα	AP-1/VCAM-1, MCP-1↑	Inflammation	83
	miR-34a↑	Inflammatory miR	?	NF-κB/VCAM-1, ICAM-1↑	Inflammation	84
	miR-21↑	Oxidative miR	SOD↓	?	Oxidation	30
	miR17*↑	Oxidative miR?	SOD, GPx, Trx2↓	?	Oxidation?	30
	miR-92a↑	NO-related miR	KLF2↓	eNOS↓	NO repression	82
Atheroprotective PS	miR
	miR-19a↑	Anti-proliferative miR	CyclinA↓	?	Antiproliferation	71
	miR-23b↑	Anti-proliferative miR	E2F↓	Rb phosphorylation↓	Antiproliferation	72
			?	CAK complex (repression)	Antiproliferation	78
	miR-101↑	Anti-proliferative miR	mTOR↓	?	Antiproliferation	79
	miR-155↑	Anti-proliferative miR	MYLK↓	RhoA	Antiproliferation Anti-proliferation	80
	miR-10a↑	Anti-inflamatory miR	GATA6↓	VCAM-1↓	Anti-inflammation	60, 76
	miR-146a↑	Anti-inflammatory miR	IRAK↓	NF-κB signaling↓	Anti-inflammation	85
	miR-708↑	Anti-inflammatory miR	IKK-γ↓	NF-κB signaling↓	Anti-inflammation	85
	miR-451↑	Anti-inflammatory miR	IL-6R↓	NF-κB signaling↓	Anti-inflammation	85
	miR-98↑	Anti-inflammatory miR	CHUK↓	NF-κB signaling↓	Anti-inflammation	85
	miR-92a↓	Anti-inflammatory miR	KLF2↑	TM ↑	Anti-inflammation	82
		NO-related miR	KLF2↑	eNOS↑	NO production	82
	miR-21↑	NO-related miR	PTEN↓	eNOS (phosphorylation)↑	NO production	87
	lncRNAs
	STEEL↓	Turnover-related lnRNA		eNOS, KLF-2↑	Turnover, migration	93
					NO production???
	MANTIS↑	Aligment-related lnRNA		Smad6, Sox18	Cell alignment	94
					Angiogenesis
	LASSIE↑	Aligment-related lnRNA			Cell alignment	95
					Cell-cell interaction
	LISPR1↑	Migration-related lnRNA		S1PR1 signaling↑	Migration	96