Skip to main content
. Author manuscript; available in PMC: 2019 Aug 7.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2019 May 11;143:106337. doi: 10.1016/j.prostaglandins.2019.106337

Table 3.

Biological effects of EPA-derived eCBs and Derivatives

Effects of Eicosapentaenoyl Ethanolamide (EPEA) References
Reduced IL-6 levels in LPS-stimulated 3T3-L1 adipocytes (47)
Reduced MCP-1 production by 50% in LPS-stimulated 3T3-L1 cells (47)
Inhibited MCF-7 cancer cell proliferation (50)
Effects of Eicosapentaenoyl Ethanolamide Epoxides (EEQ-EA)
Reduced pro-inflammatory nitric oxide and IL-6 (19)
Induced production of anti-inflammatory IL-10 in microglia (19)
Effects of Monoacylglyceride Eicosapentaenoic Acid (1-EPG)
Dose administration reduced reactivity of airway smooth muscles (75)
Reduced expression NFκβ and COX-2 (75)
Reduced trachael ring tension induced by U-46619 (76)
Reduced severity of DSS-induced colitis (77)
Reduced pro-inflammatory cytokines TNFα, IL-1β, and IL-6 (77)