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. 2019 Jul 31;10:1727. doi: 10.3389/fmicb.2019.01727

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Copyright © 2019 Silva, Taira, Dias, Souza, Nosanchuk, Travassos and Taborda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Therapeutic delivery of BMDC or MoDC pulsed or not with P10 significantly reduces pulmonary fungal burden. Mice (n = 6) were infected intratracheally with P. brasiliensis, and after 30 days the animals were treated once with MoDC or BMDC pulsed or not with P10 by subcutaneous route. The animals were euthanized 30 days after the DC treatment and the pulmonary fungal load was evaluated by CFU counts in BHI plates. Untreated mice (INFECT-only) were used as control. Data shown are representative of three independent experiments, analyzed by one-way ANOVA followed by Tukey’s post-test, where ^∗∗∗p < 0.001 in comparison to INFECT-only and ##p < 0.01 for comparison of respective DC pulsed or not with P10. ^*p < 0.05.