Table 3.

Methylation sites associated (FDR q-value ≤ 0.05) with the Epworth Sleepiness Scale (square-root transformed) in MESA either in AA (n = 132) or in the combined analysis (n = 619) along with their association in CHS AA (n = 238) or CHS combined (n = 483)

Probe	CHR	Location	Analyses race/ethnic group	Gene	Effect estimate in MESA	MESA p-valuea	MESA q-valuea	MESA interaction p-valueb	Effect estimate in CHSc	p-value in CHSc	p-value meta analysisd
cg25472882	7	1112040	Combined	C7orf50	15.26	6.59e-08	0.0237	0.312	−1.77	0.49	0.00125
cg12833508	2	224701802	AA	AP1S3	−17.31	1.38e-07	0.0393	0.00021	1.19	0.54	1.42e-02
cg26609398	16	2752235	AA	KCTD5	−14.88	2.33e-07	0.0412	0.00067	−3.30	0.028	4.95e-06
cg13687497	9	137249839	AA	RXRA	−20.98	3.66e-07	0.0393	0.00024	−3.90	0.045	2.63e-05

^aModels adjusted for age, sex, residual cell type enrichment, site of recruitment, and top five principal components calculated within the group listed in the analysis column. If Analyses column indicates ‘Combined’, adjustment was also made for self-reported race/ethnicity.

^bModels adjusted for age, sex, residual cell type enrichment, recruitment site, top five principal components in the overall sample, and self-reported race/ethnicity when testing for interaction between DNAm Beta-value and self-reported race/ethnicity in overall sample.

^cAssociation results in respective CHS analysis. p-value is based on one-sided p-values informed by the direction of effect.

^d p-value from meta-analysis of MESA and CHS. Genomic locations are provided in genome build 37.