1 |
NA (P = 0.34) |
Arhgap18, Adm, Hspb1, CD36
|
N |
Cellular homeostasis |
(13–16) |
2 |
MI (P = 0.02) |
Ifit1, Ifit2, Ifit3, Ifit3b, Usp18, Cxcl10
|
Y |
Interferon signalling |
(17) IFN signalling in CVD including MI; (18) Induction of EC proliferation by IFN |
3 |
MI (P = 0.0006) |
Myl2, Mb, Myl3, Tnnt2, Tnni3, Actc1
|
Y |
Ventricular cardiac muscle remodelling |
(19) Embryonic EC trans-differentiation to cardiac muscle cells in MI |
4 |
NA (P = 0.07) |
Klra3, Klra9, Klra10
|
Y |
Killer cell lectin-like receptor signalling |
(20) NK cell interaction with EC driving neovasculogenesis post-MI; (21) EC expression of Klra family genes; (22) CD31 expression by NK cells |
5 |
NA (P = 0.51) |
Dll4, Notch1, Hey1, Jag1, Gja4
|
Y (Hey1, Jag1, Gja4) |
Endothelial cell regulation via Notch signalling |
(23) Notch regulation of EC; (24,25) Gja4 encodes Connexin37 in EC, which regulates arterial-venous specification; (26) Gja4-deficient mice have abnormal vascular regeneration in ischaemic limb |
6 |
MI (P = 0.006) |
Plvap, Lrg1, Pbp1, Bgn, vWF
|
N |
Ventricular remodelling [via retinoic acid (RA) signalling] |
(27,28) Regulation of ventricular remodelling by Rbp1 and Bgn via RA signalling post-MI |
7 |
MI (100%) |
Ackr1, Ehd4, Tmem176a, Tmem252, Tmem176b, Selp
|
Y (Ackr1, Tmem252, Selp) |
Stalk cell markers. Tip and stalk cell-mediated neovasculogenesis |
(29,30) EC tip and stalk cell signalling; (31) Fate switching between tip and stalk cells, enhanced proliferation by stalk versus tip cells |
8 |
MI (P = 0.07) |
Fbln2, Anxa2, Col5a2, Emilin1, Hmcn1, Bgn, Mgp
|
Y (Col5a2, Mgp) |
Endothelial ECM proteins, cardiac remodelling post-MI |
(32) Cardiac remodelling in human and pigs post-MI; (33) Endothelial ECM critical for blood vessel network stabilization and maturation |
9 |
NA (P = 0.69) |
Serpina1b, Serpina1d, Serpina1e
|
Y |
Serine protease inhibitor alpha-1 antitrypsin (AAT) signalling |
(34,35) AAT therapy in ischaemic disease; (36,37) AAT is cytoprotective following ischaemic injury |
10 |
MI (P = 0.02) |
Mki67, Top2a, Cenpf, Cks2, Birc5, Cenpa, Ube2c, Cdc20
|
Y |
Proliferation and cell cycle regulation |
(38) |