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. 2019 Jul 31;10:1721. doi: 10.3389/fimmu.2019.01721

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Copyright © 2019 Hughes, Burton, Reese, Jabeen, Wright, Willis, Khoshaein, Marsh, Peachell, Sun, Dockrell, Marriott, Sabroe, Condliffe and Prince.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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WT and Peli1^−/− mice develop airway inflammation in response to repeated LPS and elastase. Peli1^−/− transgenic mice and WT littermates were given i.n. PBS (black circles) or LPS (7μg) and porcine neutrophil elastase (1.2 units, black squares) every 7 days for 4 weeks. Mice were subjected to bronchoalveolar lavage (BAL) on day 28 and inflammation assessed by enumerating total cell number in BALF by haemocytometer (A) and number/proportion of neutrophils (B,C) and macrophages (D,E) by light microscopy. Lungs were removed and stained for histological analysis. Representative images are shown (F, scale bar = 50 μm). Individual data points represent a single mouse and panels show mean ± SD. Statistically significant differences are indicated by ^*p < 0.05 (n = 3–5 A, n = 3–9 B–E).