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. 2019 Jul 31;10:1751. doi: 10.3389/fmicb.2019.01751

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Copyright © 2019 Li, Ye, Lv, Xu, Yang, Jiang, Wu, Shi, Fang, Bian, Wang, Wang, Xie, Lu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of pretreatment with Bacillus cereus on the overall changes in the gut microbial community structure during D-GalN-induced acute liver injury. (A) The α-diversity of the gut microbiome determined based on the goods_coverage index of the probiotic group compared with the PC group. (B) The principal coordinate analysis (PCoA) plot shows the β-diversity of the gut microbiome with Bray–Curtis dissimilarity derived from 16S RNA sequencing data. (C) Comparison of taxa at the bacterial genus level between the PC and B. cereus groups. Data are presented as medians with first and third quartiles. (NC group, n = 7; PC group, n = 6; B. cereus group, n = 7). ^aP < 0.05 compared with the PC group. NC, negative control; PC, positive control; PCoA, principal coordinate analysis.