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. 2019 Jun 5;10(30):7251–7259. doi: 10.1039/c9sc02162k

Table 1. Screening for optimal reaction conditions a .

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Entry TCICA (equiv.) KF (equiv.) Additive Temp. (°C) Yield (%)
1 2.0 rt
2 2.0 5.0 rt 29
3 2.0 5.0 0.1 TFA rt 27
4 4.0 5.0 rt 49
5 6.0 5.0 rt 79
6 6.0 7.0 rt 81
7 6.0 3.0 rt 75
8 2.0 3.0 50 61
9 4.0 5.0 50 62
10 4.0 6.0 40 94
11 6.0 5.0 40 26 b

aYields determined by 19F NMR using fluorobenzene as an internal standard.

bMeCN not dry.