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. 2019 Jul 31;13:356. doi: 10.3389/fncel.2019.00356

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Copyright © 2019 La Rosa, Russo, D’Amico, Petrillo, Aquilano, Lettieri-Barbato, Turchi, Bertini and Piemonte.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Frataxin depletion determines phenotypic defects in KIKO NSCs and neurons. (A,B) analysis of WT and KIKO NSCs proliferation assessed by growth curves experiments over 5 days (A), and diameter evaluation on the fifth day (B). (C) Clonogenic assay of WT and KIKO NSCs. Clonogenicity was expressed as the ratio between the observed neurospheres and plated NSCs. (D) Immunofluorescence analysis of the neuronal differentiation marker Tuj-1 in WT and KIKO NSCs cultured for 3 days in differentiating conditions. Graph on the right represents (mean ± SD) measurement of number of Tuj-1 positive cells, ^*p < 0.05. Scale bars = 100 μm.