Table 1.
ECM derived matrikines and their respective modulatory functions.
| Identified cryptid | Function | Source | References |
|---|---|---|---|
| GETGPAGPAGPIGPVGARGPA, GPQGPRGDKGETGEQ | Facilitate wound healing via enhanced cell adhesion and antioxidative activities | Bovine collagen α-1(I) chain | (109) |
| RQVFQVAYIIIKA | Facilitate wound healing via enhanced cell migration | α-1 chain laminin | (110) |
| YGDEY | Antioxidant activity | Tilapia skin gelatin hydrolysates | (111) |
| KNVLVTLYERDEGNNLLTEK | Induces MMP9 production in monocytes | SPARC glycoprotein | (112) |
| VGVAPG | Induces MMP2 production in fibroblasts | Elastin | (113) |
| RGD | Cell adhesion via integrin binding | Fibronectin | (114) |
| DGGRYY | Activates polymorphonuclear neutrophils | A-1 chain type 1 collagen | (115) |
| GHK | Chemoattractant for macrophages and mast cells | A-2 chain type 1 collagen | (116) |