TABLE 5.
Semiquantitative Differential and Topographically Selective Distribution of Neurodegenerative Changes in the Brain of Our Subject
| # | Region of interest | Tau | Amyloid | Α-SN | CD-68 | GFAP | Ubi | TDP-43 | FUS | LFB |
|---|---|---|---|---|---|---|---|---|---|---|
| 1. | Frontal lobe, right and left | 3+ | 3+ | 0 | 3+ | 3+ | 0 | 0 | 0 | 1+ |
| 2. | Temporal lobe, right and left | 3+ | 3+ | 0 | 3+ | 3+ | 0 | 0 | 0 | 1+ |
| 3. | Parietal lobe, right and left | 3+ | 3+ | 0 | 3+ | 3+ | 0 | 0 | 0 | 1+ |
| 4. | Occipital lobe, right and left | 1+ | 2+ | 0 | 3+ | 3+ | 0 | 0 | 0 | 1+ |
| 9. | Hippocampus, right and left | 3+ | 2+ | 0 | 3+ | 3+ | 0 | 0 | 0 | 1+ |
| 5. | Pulvinar/posterior thalamus, right and left | 3+ | 1+ | 0 | 3+ | 3+ | 0 | 0 | 0 | 1+ |
| 6. | Cingulate gyrus, corpus callosum, and caudate nucleus, right and left | 3+ | 2+ | 0 | 3+ | 3+ | 0 | 0 | 0 | 1+ |
| 7. | Amygdala, right and left, with entorhinal cortex | 3+ | 1+ | 0 | 3+ | 3+ | 0 | 1+ | 0 | 1+ |
| 8. | Insula cortex, right and left | 3+ | 3+ | 0 | 3+ | 3+ | 0 | 0 | 0 | – |
| Putamen, right and left | 3+ | 1+ | 0 | 3+ | 3+ | 0 | 0 | 0 | – | |
| Globus pallidus, right and left | 3+ | 1+ | 0 | 3+ | 3+ | 0 | 0 | 0 | – | |
| Internal, external, and extreme capsules, right and left | 3+ | 0 | 0 | 3+ | 3+ | 0 | 0 | 0 | 1+ | |
| 9. | Splenium of the corpus callosum | 2+ | 0 | 0 | 3+ | 3+ | 0 | 0 | 0 | 1+ |
| 10. | Motor cortex, right and left | 3+ | 2+ | 0 | 3+ | 3+ | 0 | 0 | 0 | 1+ |
| 11. | Prefrontal lobe, right and left | 3+ | 3+ | 0 | 3+ | 3+ | 0 | 0 | 0 | 1+ |
| 12. | Midbrain, rostral and caudal | 3+ | 1+ | 0 | 3+ | 3+ | 0 | 2+ | 0 | 1+ |
| Hypothalamus | 3+ | 1+ | 0 | 3+ | 3+ | 0 | 2+ | 0 | 1+ | |
| 13. | Pons, tegmental nuclei, rostral and caudal | 3+ | 1+ | 0 | 3+ | 3+ | 0 | 0 | 0 | 1+ |
| Pontine nuclei and basis pontis, rostral and caudal | 1+ | 0 | 0 | 3+ | 2+ | 0 | 0 | 0 | 1+ | |
| 14. | Medulla oblongata, rostral and caudal | 2+ | 0 | 0 | 3+ | 2+ | 0 | 0 | 0 | 1+ |
| 15. | Medulla oblongata, caudal | 2+ | 0 | 0 | 3+ | 2+ | 0 | 0 | 0 | 1+ |
| 16. | Cerebellum, cortex, right and left | 0 | 0 | 0 | 1+ | 3+ | 0 | 0 | 0 | 1+ |
| Dentate nucleus and subcortical nuclei, right and left | 2+ | 0 | 0 | 3+ | 3+ | 0 | 0 | 0 | 1+ | |
| 17. | Spinal cord, cervical | 2+ | 0 | 0 | 3+ | 1+ | 0 | 0 | 0 | 1+ |
| 18. | Spinal cord, thoracic | 2+ | 0 | 0 | 3+ | 1+ | 0 | 0 | 0 | 1+ |
| 19. | Spinal cord, lumbar | 2+ | 0 | 0 | 3+ | 1+ | 0 | 1+ | 0 | 1+ |
CERAD-based semiquantitative differential and topographically selective distribution of inflammatory changes and neuropathological substrates in the brain of our patient. He had received an antemortem [F-18]FDDNP-PET scan 52 mo prior to his death.
Tau, PHF-tau; Amyloid, beta-A4 amyloid; A-SN, alpha-synuclein; GFAP, glial fibrillary acidic protein; Ubi, ubiquitin; TDP-43, TAR DNA-binding protein 43; FUS, fused in sarcoma protein; LFB, luxol fast blue-cresyl violet. The density of pathology and proteinopathy: 0: None; 1: Sparse; 2: Moderate; 3: Frequent.