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. 2019 Jul 31;9:678. doi: 10.3389/fonc.2019.00678

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Copyright © 2019 Gong, Xu, Xiang, Shan and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The results of qRT-PCR showed that (A) the expression of hsa-miR-499a-5p and hsa-miR-499a-3p in high-tobacco exposed HNSCC was higher than those in low-tobacco and medium-tobacco exposed HNSCC, and the expression of hsa-miR-499a-5p and hsa-miR-499a-3p in medium-tobacco exposed HNSCC was higher than those in low-tobacco exposed HNSCC. (B) The expression of AEBP2 and ZNRF1 in high-tobacco exposed HNSCC was lower than those in low-tobacco and medium-tobacco exposed HNSCC, and the expression of AEBP2 and ZNRF1 in medium-tobacco exposed HNSCC was lower than those in low-tobacco exposed HNSCC (^*P < 0.05, ^**P < 0.01).