Table 1.

Association of all rare, non-synonymous variants at LOXL1 and risk of exfoliation syndrome. No additional filters by functional effect prediction algorithms were applied. Frequencies for rare variant carriers are given in percentages.

Collection	N cases	N controls	Allele burden cases	Allele burden controls	Carrier freq cases	Carrier freq controls	Allele OR	L95	U95	P
Japanese	2827	3013	34	100	1.20	3.32	0.36	0.24	0.53	8.03 × 10−8
Greece	355	1075	3	17	0.85	1.58	0.53	0.16	1.82	0.44
Italy	454	267	10	3	2.20	1.12	1.97	0.54	7.19	0.39
Russia	476	859	2	5	0.42	0.58	0.72	0.14	3.72	1
USA	212	161	2	2	0.94	1.24	0.76	0.11	5.41	1
Mexico	116	205	2	9	1.72	4.39	0.39	0.083	1.81	0.34
South Africa	95	250	1	21	1.05	8.40	0.12	0.016	0.90	0.014
India	648	263	12	8	1.85	3.04	0.61	0.25	1.49	0.32
Pakistan	383	186	7	4	1.83	2.15	0.85	0.25	2.92	0.76
Stratified meta-analysis for all sequenced collections							0.46	0.34	0.62	4.2 × 10−7