Figure 1.

Schematic illustration of N₃‐labeled T cell membrane‐biomimetic nanoparticles with dual‐targeting mechanism for highly efficient photothermal therapy. A) Synthesis of N₃‐TINPs. Extracting N₃‐labeling T cell membranes were coated on prepared ICG‐PLGA polymeric cores by extrusion to form N₃‐TINPs. B) Tumor cells carrying the BCN group via natural glycometabolic labeling by pretreatment with Ac₄ManN‐BCN. N₃‐TINPs could target tumor through immune recognition of T cell membrane and bioorthogonal reaction between BCN and N₃ groups, and effectively eliminate mouse tumors through ICG‐mediated photothermal effects.