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. 2019 May 24;6(15):1900295. doi: 10.1002/advs.201900295

Figure 8.

Figure 8

IGF2 supplementation improves human early embryos development in vitro. A) Time line of human oocyte maturation to early embryo growth up to the blastocyst stage, highlighting critical times between the stages and the predicted in vitro culture development in medium with and without IGF2 after intracytoplasmic sperm injection. Red arrows indicate the time duration of IGF2 treatment from zygote to blastocyst formation. B) Improved blastocyst formation of human embryos after IGF2 treatment. Total numbers of zygotes (n) used are indicated. C) Morphology of embryos after in vitro culture with or without IGF2 in the culture medium. Scale bar, 100 µm.