Figure 9.

Cell membrane‐based nanotherapeutics targeting cardiovascular diseases. A) Schematic representation of platelet membrane‐coated nanoparticle (PNP) targeting different components of atherosclerotic plaques, including activated endothelium, foam cells, and collagen. B) In vivo targeting and live imaging of aortic arch from ApoE KO mice confirmed the presence of atherosclerotic plaques. Reproduced with permission.109 Copyright 2017, American Chemical Society. C) Schematic illustration of the biochemical design and study model of CMMPs. MPs were fabricated from PLGA and conditioned media of human CSCs, and then MPs were coated with membrane fragments of CSCs to form CMMPs. D) Masson's trichrome‐stained myocardial sections 4 weeks after treatment with Control PBS, Control MP1, CMMPs, or CSCs. Reproduced with permission.110 Copyright 2017, Nature Publishing Group.