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. 2019 Jun 7;8(9):e1621676. doi: 10.1080/2162402X.2019.1621676

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© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 7. — Analysis of cytokines in cocultures of UniCAR-armed Tconvs and autologous Tregs. Cocultivation of UniCAR-endowed Tconvs and (a) TCR- or (b) UniCAR-activated Tregs was performed in the presence of 6 pmol αPSCA TM (a) at indicated Treg:Tconv ratios or (b) at a 1:1 ratio of both T cell populations. PC3-PSCA cells were added at a 5:1 UniCAR T cell to target cell ratio. After 48 h, cell-free supernatants were collected and analyzed for cytokine amounts using a MACSPlex Cytokine Kit. Concentration of indicated cytokines are shown as mean ± SEM for three individual donors. Statistical significance was calculated between individual UniCAR constructs using 1-way ANOVA with Bonferroni post hoc test (*p < .05, **p < .01, (a) with respect to UniCAR 28/ζ-engrafted Tconvs).