Table 2.
Principal clinical and diagnostic findings for these four cases
| Case | ||||
|---|---|---|---|---|
| 1 | 2 | 3 | 4 | |
| General information | ||||
| Age (years) | 12 | 6 | 51 | 43 |
| Gender | Male | Female | Male | Male |
| Date of onset | August 1, 2014 | May 27, 2014 | July 14, 2014 | April 30, 2015 |
| Date of admission | August 12, 2014 | May 30, 2014 | July 17, 2014 | May 6, 2015 |
| Duration of illness (days) | 22 | 5 | 5 | 7 |
| Duration of hospitalization (days) | 10 | 2 | 2 | 1 |
| Outcome | Survived | Fatal | Fatal | Fatal |
| Summary of clinical findings | ||||
| Highest body temperature (°C) | 38.4 | 40.4 | 39 | 36.5* |
| Lowest blood pressure (mmHg) | 89/47 | 35/21 | 60/40 | 90/30 |
| Heart rate first recorded (bpm) | 120 | 110 | 100 | 108 |
| Respiratory frequency first recorded (rpm) | 20 | 20 | 18 | 50 |
| Lowest platelet value (per µL) | 30,000 | 7,000 | 31,000 | 15,000 |
| Leukocytes first recorded (per µL) | 4,500 | 3,970 | 4,570 | 5,900 |
| Neutrophils first recorded (per µL) | 3,510 | 3,005 | 4,067 | 5,428 |
| Lowest leukocytes value (per µL) | 2,300 | 3,970 | 2,900 | 5,900 |
| Lowest neutrophil value (per µL) | 1,909 | 3,005 | 2,146 | 5,428 |
| Presence of signs and symptoms | ||||
| Signs of bleeding | Yes | Yes | Yes | No |
| Oliguria | Yes | No | Yes | No |
| Dehydration | Yes | Yes | Yes | Yes |
| Fever | Yes | Yes | Yes | Yes* |
| Headache | Yes | Yes | No | No |
| Chill | No | Yes | No | No |
| Abdominal pain | Yes | Yes | Yes | Yes |
| Emesis | Yes | Yes | Yes | Yes |
| Diarrhea | Yes | Yes | Yes | Yes |
| Anasarca | Yes | Yes | No | No |
| Choluria | No | No | Yes | Yes |
| Maculopapular rash | Yes | Yes | Yes | Yes |
| Myalgia | Yes | Yes | Yes | Yes |
| Arthralgia | No | Yes | No | Yes |
| Asthenia | Yes | Yes | No | No |
| Retro-orbital pain | Yes | Yes | No | No |
| Hepatomegaly | No | Yes | No | Yes |
| Jaundice | No | No | No | Yes |
| Laboratory findings | ||||
| Alterations in aminotransferases | Yes | Yes | Yes | Yes |
| Coagulopathy | Yes | Yes | Yes | Yes |
| Elevated creatinine | No | Yes | Yes | Yes |
| Diagnostic tests | ||||
| Immunofluorescence antibody assay | Yes (P) | ND | ND | Yes (N) |
| Polymerase chain reaction | ND | ND | ND | Yes (P) |
| Bacterial isolation | ND | ND | ND | Yes (P) |
N = negative; ND = no data; P = positive.
* We do not have a record of the body temperature before case 4 was referred to a hospital in Medellin.