Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jul 30;55(3):671–683. doi: 10.3892/ijo.2019.4852

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Wu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Downregulation of miR-501-3p increases cyclinD1 and c-Myc expression via targeting APC in colorectal cancer cells. (A) Downregulation of miR-501-3p decreased cyclinD1 and c-Myc mRNA expression levels, while APC silencing reversed the downregulation of cyclinD1 and c-Myc in HCT116 cells and in (B) Caco2 cells. (C) Downregulation of miR-501-3p decreased cyclinD1 and c-Myc protein expression levels, while APC silencing reversed the downregulation of cyclinD1 and c-Myc in HCT116 cells. (D) Quantitative analysis of cyclinD1 and c-Myc protein expression levels in C. (E) Downregulation of miR-501-3p decreased cyclinD1 and c-Myc protein expression levels, while APC silencing reversed downregulation of cyclinD1 and c-Myc in Caco2 cells. (F) Quantitative analysis of cyclinD1 and c-Myc protein expression levels in E. ^**P<0.01 and ^***P<0.001, with comparisons indicated by lines. miR, microRNA; APC, adenomatous polyposis coli; NC, negative control; si, small interfering.