Immunostaining of the Piezo1 channel in human prostate carcinoma and paracarcinoma tissues. (A) Representative immunohistochemistry staining of Piezo1 (brown color). The right panel was extended from the square in left panel. (B) Summary data of Piezo1 channel expression in human prostate carcinoma (n=44) and paracarcinoma tissues (n=26). In comparison with paracarcinoma tissue (mean H-score 79.22±7.73), the prostate carcinoma tissue (mean H-score 142.90±5.22) showed a higher expression of Piezo1. (C) Piezo1 mRNA expression in patients with PRAD from the UALCAN database (normal, n=52; primary tumor, n=497; P=1.62448×10−12). Data are shown as the mean ± standard error of the mean. **P<0.01. PRAD, prostate adenocarcinoma; Piezo1, piezo type mechanosensitive ion channel component 1; TCGA, The Cancer Genome Atlas.