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. 2019 Jul 15;55(3):629–644. doi: 10.3892/ijo.2019.4839

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Copyright: © Han et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Piezo1 promotes tumorigenesis of prostate cancer. High expression of Piezo1 channel and its activation may induce Ca²⁺ influx. Subsequently, intracellular Ca²⁺ increase directly or indirectly activates Akt, mTOR, upregulating the expression of cyclin D1 and CDK4. Phosphorylation of Akt and mTOR, followed by activation of the cyclin D1/CDK4 complex, may facilitate cell survival, cell cycle progression, cell proliferation and migration, which in turn may promote the tumorigenesis of prostate cancer.