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. 2019 Jul 15;55(3):629–644. doi: 10.3892/ijo.2019.4839

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Copyright: © Han et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Inhibition of prostate cancer xenograft tumor growth by downregulation of Piezo1 in vivo. (A) Representative images of DU145/Luc xenograft tumor mice before (day 17, implanted for 17 days) and after (days 24, 31, and 38, implanted for 24, 31 and 38 days, respectively) treatment with saline, GsMTx4, AAV-DsRed2 or AAV-piezo1-shRNA-DsRed2. (B) The photon counts before (day 17) intratumoral treatment (top panel) and the altered photon counts after (day 24, 31 and 38) intratumoral treatment (botto panel). (C) Tumors were isolated from nude DU145/Luc xenograft prostate tumor mice in each group on day 38. (D) Measurements of tumor weight from tumors collected from nude DU145/Luc xenograft mice in each group on the day 38. Data are presented as the mean ± SEM. ^*P<0.05. DU145/Luc, luciferase-labeled DU145 cells; shRNA, short hairpin RNA; Piezo1, piezo type mechanosensitive ion channel component 1; ns, not significant.