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. 2019 Jul 15;55(3):629–644. doi: 10.3892/ijo.2019.4839

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Copyright: © Han et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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The effect of Piezo1 knockdown on calcium signals induced by mechanical stimulation and the specific Piezo1 channel agonist Yoda1. Analysis of dynamic Ca²⁺ signals induced by mechanical stimulation (A) and by Yoda1 (B) between control shRNA (Black) and Piezo1 shRNA group (Red). (C and D) The AUC in different groups was calculated and compared. Data are presented as the mean ± SEM. ^**P<0.01 vs. control shRNA. shRNA, short hairpin RNA; Piezo1, piezo type mechanosensitive ion channel component 1; IF, intracellular fluorescence; AUC, area under the curve.