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. 2019 Jul 26;55(3):645–656. doi: 10.3892/ijo.2019.4849

Figure 2.

Figure 2

RAC2 expression is upregulated in ccRCC, and is associated with various clinicopathological parameters in ccRCC tissues. The mRNA expression levels of RAC2 were obtained from TCGA dataset, which contained 72 adjacent normal tissues and 534 ccRCC tissues. (A) RAC2 expression was higher in the ccRCC tissues than in the adjacent normal tissues in the 72 paired tissues from patients with ccRCC. The mRNA expression levels of RAC2 were increased in (B) ccRCC tissues than in normal tissues in TCGA, (C) Gumz renal database, (D) Lenburg renal dataset, (E) Jones renal dataset and (F) Yusenko renal dataset. The high expression of RAC2 mRNA was associated with various clinicopathological factors: (G) T stage, (H) lymph node metastasis, (I) distant metastases, (J) TNM stage and (K) G grade. ****P<0.0001; ***P<0.001; **P<0.01. RAC2, Rac family small GTPase 2; ccRCC, clear cell renal cell carcinoma; KIRC, kidney renal clear cell carcinoma; TCGA, The Cancer Genome Atlas; TNM, Tumor-Node-Metastasis.