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Rat Model of OHT
IOP was significantly elevated from the time immediately after suturing (54 ± 7 mm Hg) until the end of the experiment (control [n = 15], 13 ± 2 mm Hg; OHT [n = 30], 27 ± 3 mm Hg at 3 months) (A). Immunostaining of BRN-3a at 4 weeks revealed a markedly decreased number of RGCs in OHT eyes compared with the control (B and C). Data are means ± SEM. Scale bars, 20 μm. OHT, ocular hypertension.
