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. 2019 Jul 10;14:197–205. doi: 10.1016/j.omtm.2019.06.009

Figure 2.

Figure 2

scAAV Transduction Patterns in the TM and Ciliary Body of OHT and Control Eyes

In vector uninjected eyes, EGFP expression was not detected in both normotensive (A and E) and OHT (I and M) eyes. In control eyes with vector injection, EGFP expression in the TM and parts of the ciliary body was scarce after scAAV2 (B and F) and scAAV5 (C and G) transduction and absent after scAAV8 transduction (D and H). In OHT eyes, EGFP expression in the TM and ciliary body was markedly increased after scAAV2 (J and N) and scAAV5 (K and O) transduction. Specifically, in OHT eyes, scAAV2 transduction was localized in both the TM and ciliary body, whereas scAAV5 transduction was localized in the TM and Schlemm’s canal; however, scAAV8 transduction was not observed in the TM but was high in the ciliary body (L and P). Images are representatives of 45 mice analyzed (30 for OHT group and 15 for control). Scale bars, 20 μm.