Figure 3.

Cross-Sectional Images of the Corneal Endothelium and Iris of Control and OHT Eyes Administered scAAV2, scAAV5, or scAAV8

No EGFP expression was detectable in both normotensive (A and E) and OHT, vector uninjected (I and M) eyes. EGFP expression was scarce on the posterior surface of the iris and corneal endothelium of control eyes administered scAAV2 (B and F), scAAV5 (C and G), and scAAV8 (D and H). Transduction of scAAV2 (J and N), scAAV5 (K and O), and scAAV8 (L and P) was markedly increased in the iris and corneal endothelium of OHT eyes. Pictures are representatives of 45 mice analyzed (30 for OHT group and 15 for control). Scale bars, 20 μm.