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. 2019 Jul 10;14:197–205. doi: 10.1016/j.omtm.2019.06.009

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Cross-Sectional Images of the TM, Ciliary Body, Iris, and Corneal Endothelium of OHT and Control Eyes Immunostained for GFP (Green) and TSP-1 (Red) at 3 Months after Circumlimbal Suture

Increased expression of EGFP persisted in OHT eyes until 3 months after suturing. Transduction of scAAV2 was enhanced in the TM and ciliary body (A), and that of scAAV5 in the TM and Schlemm’s canal (B) of OHT eyes, similar to the findings at 1 month. Transduction of scAAV8 was enhanced only in the ciliary body, similar to that at 1 month (C). Transduction of scAAV2 (D and G), scAAV5 (E and H), and scAAV8 (F and I) was enhanced in the iris and corneal endothelium. Images are representatives of 45 mice analyzed (30 for OHT group and 15 for control). Scale bars, 20 μm.